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7 In addition, FIN56-induced ferroptosis is related to autophagy, and inhibition of autophagy at different stages could weaken FIN56-induced lipid peroxidation and GPX4 degradation

Strikingly, the upregulation of immune-related genes in these precursor lesions was shown to be independent of mutational rate and neoantigen load, suggesting that immune activation occurs early in the process of LS-associated tumorigenesis and is not merely the consequence of accumulating somatic mutations, thereby supporting the concept of immunoprevention as a prophylactic strategy in the management of LS [66]

PGLS, 6-Phosphogluconolactonase

[ 502 ] A separate study demonstrated that RE decreased oxidative stress and inflammation by suppressing BACH1, thereby ameliorating hepatic ischemiareperfusion injury (HIRI)